Conducting trials

The challenges of conducting clinical trials for neglected tropical diseases

Clinical research involving human subjects is driven mainly by the availability of novel products, devices or interventions that require further investigations to determine their safety and efficacy. The designs of clinical trials are critical to ensuring scientific validity and reproducibility of the results and it is essential that ethical approval is obtained by well-informed ethical committ...

Recommendations for conducting mindfulness based cognitive therapy trials.

Key considerations for conducting Chinese medicine clinical trials in hospitals

Conducting clinical trials of Chinese medicines (CM) in hospitals presents challenges for researchers. The success of hospital-based CM clinical trials may be influenced by the protocol design, including the maintenance of CM theory in compliance with scientific rigour and hospital guidelines and justified treatment approaches with results that can translate into clinical practice. Other influe...

Conducting Randomized Controlled Trials for the Treatment of Enteric Fever

TO THE EDITOR—We read with great interest the recent article by Meltzer et al, “A Large Outbreak of Salmonella Paratyphi A Infection Among Israeli Travelers to Nepal” [1], and we would like to raise a few issues. The authors made the point that randomized controlled trials (RCTs) are difficult to conduct in developing countries. However, in Nepal, over the last decade we have carried out a seri...

Conducting clinical trials over the internet: feasibility study.

The possibility of conducting clinical trials entirely on line is an enticing but relatively unexplored medical application of the internet. The penetrance of the internet in the population offers the possibility of rapid recruitment of participants, and technological advances enable instant collection of data in a secure and confidential manner. These attributes could theoretically accelerate ...